Millions of people live with the visible aftermath of acne , pitted skin, uneven texture, and the quiet knock to confidence that follows. Most treatments promise results that rarely match the reality. Rejuran is different. Derived from salmon DNA, this Korean-born injectable works at a cellular level to genuinely repair damaged skin rather than simply masking it.
Clinical studies show that 72% of patients see visible scar reduction after just three sessions, with collagen density rising by 34% in treated areas (MJS Medicals, 2025). Yet in the UK, a full course still costs upwards of £1,500 , prompting a growing number of British patients to explore treatment abroad.
This guide covers everything you need to know: how Rejuran scar treatment works, what Rejuran eye treatment can achieve, and the honest cost comparison between the UK and Turkey.
Key Takeaways
- Rejuran uses salmon-derived polynucleotides (PDRN) to stimulate collagen and repair skin at a cellular level
- Rejuran scar treatment reduces rolling and boxcar scar depth by 40–60% over three sessions (fillersfairy.com, 2025)
- Rejuran eye (also called Rejuran I) specifically targets the under-eye area , tightening skin, reducing dark circles, and improving fine lines
- A full three-session course costs £900–£1,800 in the UK; the equivalent in Turkey runs £250–£500, with all-inclusive packages available
- Turkey’s leading aesthetic clinics hold JCI and Turkish Ministry of Health accreditation, offering European-standard care at a fraction of the UK price
What Is Rejuran and How Does It Actually Work?
Rejuran is a polynucleotide (PN) injectable treatment originating from South Korea, where it has been a staple of dermatology clinics for over a decade. Its active ingredient — polydeoxyribonucleotide (PDRN) — is extracted from salmon sperm DNA, which shares remarkable structural similarity with human DNA.
When injected into the dermis, PDRN binds to adenosine A2A receptors on skin cells. This triggers a cascade of biological activity: fibroblasts (the cells responsible for collagen and elastin production) are activated, inflammation is suppressed, and the skin’s own repair mechanisms switch on. In one clinical trial involving 150 patients, PDRN treatment improved hydration, barrier function, and cellular turnover simultaneously (Kwon et al., 2021).
What makes Rejuran stand out from other skin boosters is this regenerative mechanism. It isn’t adding volume or filling tissue from the outside; it’s instructing your skin to rebuild from within. Results are therefore gradual but more durable ,most patients notice visible improvement between two and four weeks after each session, with results peaking at around three months.
The treatment takes 20–30 minutes. A numbing cream is applied beforehand to keep discomfort minimal. Temporary papules (small raised bumps at the injection sites) may appear but typically resolve within 24 hours. There’s no meaningful downtime.
Does Rejuran Work for Scars?
Rejuran scar treatment is one of the most compelling applications of PDRN technology. Acne scarring , particularly rolling, boxcar, and icepick scars , results from structural damage to the dermis that the skin cannot fully repair on its own. Rejuran directly addresses that gap.
A 2023 study found that patients with rolling and boxcar scars measuring 0.5–2mm in depth achieved a 40–60% improvement after three treatment sessions. Collagen density in treated areas increased by 34%, and 72% of participants saw visible scar reduction.
Icepick scars ,the narrowest and deepest type, respond less well on their own and are often combined with TCA cross-linking for optimal results.
The reason Rejuran scar treatment works where other injectables fall short is fibroblast activation. PDRN signals skin cells to rebuild Type I and III collagen, the structural proteins directly responsible for scar remodelling.
Rejuran scar treatment works best as a course. Three sessions, spaced four weeks apart, is the standard protocol. Optimal improvement is visible at 8–12 weeks post-course. For deeper scars, combining Rejuran with microneedling can extend results by two to three months and increases efficacy by roughly 20–40% (MJS Medicals, 2025).
PDRN-based treatments (Rejuran) have demonstrated 40–60% improvement in rolling and boxcar scar depth after three sessions spaced four weeks apart, with collagen density rising by 34% in treated areas. The mechanism involves fibroblast activation and IL-6 suppression, producing results that are gradual but structurally durable (fillersfairy.com, 2025).
What Is Rejuran Eye Treatment ?
The skin under the eyes is thinner and more delicate than anywhere else on the face. It’s also one of the first places to show the signs of fatigue, ageing, and stress. Rejuran eye ,clinically known as Rejuran I, is a specialised formulation designed specifically for this periorbital zone.
Rejuran I differs from standard Rejuran Healer in its concentration and viscosity, making it safe and effective for the fragile under-eye tissue. It targets four distinct concerns:
Dark circles: Rejuran eye improves microcirculation and thickens the skin, making underlying blood vessels less visible. It’s most effective for vascular dark circles rather than pigmentation-driven darkness.
Under-eye hollows and bags: By stimulating collagen and elastin, Rejuran I gradually restores structural support beneath the eye, reducing the shadow effect of tear trough hollowing (TT Aesthetics, 2026).
Fine lines and crepey texture: Increased dermal thickness smooths the paper-thin lines that form with age and dehydration.
Overall brightness: Enhanced cellular turnover produces a more rested, refreshed appearance over the course of a treatment programme.
Patients typically need two to three sessions of Rejuran eye, spaced four weeks apart, with results becoming noticeable around two weeks after the first treatment. One patient case study documented visible reduction in under-eye bags by two weeks post-treatment, with zero bruising and a return to work the following day.
Rejuran eye isn’t a replacement for fillers when volume loss is severe. For deep tear troughs, a combination approach, often recommended by professional doctors. The key is an honest consultation before committing to either treatment alone.
UK vs Turkey: The Real Cost of Rejuran Treatment
This is the section many British patients want straight answers on. Let’s be direct about the numbers.
In the UK, a single Rejuran session ranges from £400 to £800, depending on the clinic’s location, the practitioner’s credentials, and which formulation is used. London clinics typically sit at the higher end , some Harley Street practices charge considerably more. A standard three-session course therefore costs £1200 to £2100 in total, before any add-ons.
In Turkey — and Istanbul in particular — the same treatment is available for £200–£350 per session at reputable accredited clinics.
Trio clinic offer all-inclusive packages that cover consultation, treatment, and follow-up care.
Frequently Asked Questions
How many Rejuran scar sessions will I need?
Most patients require three sessions, spaced four weeks apart, for optimal results. Clinical studies show that 72% of patients see visible scar reduction after this standard course, with improvement continuing to build over 8–12 weeks post-treatment. More severe scarring may benefit from a fourth session or combination with microneedling.
Is Rejuran eye treatment safe for sensitive under-eye skin?
Yes. Rejuran I is specifically formulated for the periorbital zone, with a modified concentration and viscosity suited to the thin, delicate skin beneath the eyes. Clinical studies on PDRN products have shown no severe adverse effects such as immunological or allergic responses, as the DNA fragments are highly biocompatible with human tissue.
How long do Rejuran results last?
Results from a full course typically last six to twelve months, depending on skin condition, age, and lifestyle factors. Annual maintenance sessions are recommended to preserve outcomes. Patients who combine Rejuran with adjunct treatments such as RF microneedling or PICO laser may extend results by two to three months.
Can I combine Rejuran scar and Rejuran eye treatment in one trip to Turkey?
Yes, and many UK patients travelling to Istanbul do exactly this. Both Rejuran scar and Rejuran eye treatments can be administered in the same session. A reputable clinic will assess your skin comprehensively and create a single treatment plan addressing both concerns, maximising the value of your trip.
Is Rejuran treatment painful?
The procedure involves multiple small injections, but a topical numbing cream is applied 20–30 minutes beforehand. Most patients report minimal discomfort. Temporary papules and mild redness are normal within the first 24 hours. The majority of patients feel confident returning to their normal routine the following day.
